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2 edition of Studies on aspects of the pathophysiology of rotavirus-induced diarrhoea found in the catalog.

Studies on aspects of the pathophysiology of rotavirus-induced diarrhoea

Julie Collins

Studies on aspects of the pathophysiology of rotavirus-induced diarrhoea

by Julie Collins

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  • 12 Currently reading

Published by Universityof Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Birmingham, Dept of Microbiology, 1988.

StatementJulie Collins.
ID Numbers
Open LibraryOL13902480M

PDF Drive is your search engine for PDF files. As of today we h, eBooks for you to download for free. No annoying ads, no download limits, enjoy it . Pathophysiology is the study of abnormalities in physiologic functioning of living beings and seeks to reveal physiologic responses of organisms to disruptions in its internal or external environment (pg. ).

What Is Rotavirus? Rotavirus is a virus that causes diarrhea and other intestinal symptoms. It’s very contagious and is the most common cause of diarrhea in infants and young children worldwide. Diarrhea in neonatal calves is due to one or more causes. Metabolic acidosis is common in diarrheic calves. Calves dying with diarrhea gnerally tend to have low venous blood pH (between and 7.

  Rotavirus is a type of infection that’s most common in children under the age of 5. It’s highly contagious and easily transmittable. While it occurs most often in young children, adults can. pendent, and enhanced by glucose-containing perfusion solutions. Theophylline induced net secretion of water by control intestinal tissue. Water transport by rotavirus-infected lower small intestine was significantly depressed as compared to control levels, and rotavirus-infected middle small intestine exhibited net secretion of water. Upper small intestine and colon from infected animals did.


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Studies on aspects of the pathophysiology of rotavirus-induced diarrhoea by Julie Collins Download PDF EPUB FB2

The research group around John Stephen published in the late s a series of studies of various aspects of Rotavirus-induced intestinal secretion in newborn mice.

On the basis of these studies they proposed a rather elaborate hypothesis regarding the pathophysiology of virus-induced intestinal by: Abstract. The pathogenesis of diarrhea caused by rotavirus infection was studied in miniature swine piglets.

The animals were inoculated orally with 2×10 7 plaque-forming units of porcine rotavirus (OSU strain). During the height of diarrhea, intestinal function was investigated by in vivo perfusion of a cm segment of proximal jejunum and a cm segment of distal by:   These data support a new mechanism of rotavirus‐induced diarrhoea whereby a viral enterotoxin triggers a signal transduction pathway that alters epithelial cell permeability and chloride secretion.

This new information about how a gastrointestinal virus causes disease demonstrates common pathogenic mechanisms for viral and bacterial pathogens Cited by: Abstract.

Rotaviruses, members of the family Reoviridae, are nonenveloped cytopathic viruses that have a very exquisite tropism, infecting mainly mature enterocytes on the tips of the small intestinal villi and causing a severe gastroenteritis in children and in the young of many animal the past few years we have learned about the interactions of rotaviruses with cell surface.

Pathogenesis of the rotavirus takes place in the intestine where virus replication takes place and severe watery diarrhea takes place. Rotavirus protein number 4 plays an important role in causing the diarrhea and the rotavirus clinical manifestations.

This includes studies of the innate immune response to rotavirus and of disease pathophysiology, including defining the molecular mechanisms of rotavirus-induced diarrhoea and.

PATHOGENESIS AND HISTOPATHOLOGY At least three factors are thought to play a role in the pathogenesis of rotavirus-induced diarrhea: loss of brush border enzymes, the direct effect of the rotavirus enterotoxin NSP4, and activation of the enteric nervous system.

In vivo, IgY produced against murine, human and simian strains of rotavirus prevented rotavirus-induced diarrhea in mice (Yolken et al, ; Ebina, ). The anti-rotavirus effect was seen both when administered before and after viral challenge, suggesting its use for both the prevention and treatment of rotavirus gastroenteritis (Hatta et.

hospitalized with rotavirus-induced diarrhea admitted to our. pathophysiology is not yet fully understood. and development of cost effective antiviral drugs remain an important aspect of.

Many aspects of rotavirus-induced diarrhea are linked to intracellular expression of NSP4 (54) or secretion of an NSP4 fragment (amino acids (49,53)including increases in intracellular calcium and.

The peak infection age range with rotavirus is 3–24 months, the highest rate being between the ages of 6–11 reported prevalence of rotavirus diarrhoea among children below 5 years hospitalized with diarrhoea from global surveillance networks and hospital based studies varies greatly ranging from 6 to 56% [8, 9].

Epidemiological and clinical studies of rotavirus-induced diarrhea in China from– Article in Human Vaccines and Immunotherapeutics 10(12) December with 13 Reads. A prospective study conducted in the United States in children aged months in community settings before the introduction of rotavirus vaccine found that the highest incidence of acute diarrhea was in January and August, with an overall incidence of episodes per person-year.

[] Close to 90% of episodes were acute (ie, lasting. A study using data from the Nationwide Inpatient Sample analyzed rotavirus-coded and cause-unspecified gastroenteritis discharges over a year period and found there were significant reductions in rate ratios (RR) of rotavirus-coded gastroenteritis during in the year age group (RR, ), those aged years (RR, ), and.

Consequently, the prevalence of human enteric coronaviruses (HECVs) is unknown, and while they have been detected in studies in several countries, 16,24,45,62,– they are not clearly associated with disease. In studies that have compared rates of HECV detection in stools from patients with diarrhea versus controls, the results are mixed.

An in vitro model to study aspects of the pathophysiology of murine rotavirus-induced diarrhoea. Starkey WG(1), Candy DC, Thornber D, Collins J, Spencer AJ, Osborne MP, Stephen J. Author information: (1)Department of Microbiology, University of Birmingham, U.K. Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked clinical hurdle in cancer management.

Chemotherapy-induced constipation (CIC) and Diarrhea (CID) present a constant challenge in the efficient and tolerable treatment of cancer and are amongst the primary contributors to dose reductions, delays and cessation of treatment. The diarrhoea may clear up in about three days but, in some cases, it can last for up to nine days.

Your child may also have some uncomfortable stomach cramps. These may ease off after each time they pass some diarrhoea. With vomiting and diarrhoea, there is a risk of your child becoming lacking in fluid in their body (dehydrated).

Not only do these two observations illustrate that the pathophysiology of rotavirus disease is complex and most likely involves several mechanisms, of which some are age dependent, but also, and more important, this study shows for the first time that the absence of clinical diarrhea in adult mice is not solely a consequence of increased absorption of water in the colon, as has been previously suggested.

Hepatocellular death is a characteristic feature of many different liver diseases such as cholestasis, viral hepatitis, fatty liver disease, and drug-induced liver injury. Clinical and experimental studies indicate that necrosis and apoptosis are two main patterns of hepatocellular death, acting as the end stage of.

An in vitro model to study aspects of the pathophysiology of murine rotavirus-induced diarrhoea. J Pediatr Gastroenterol Nutr. Apr; 10 (3)– Vonderfecht SL, Huber AC, Eiden J, Mader LC, Yolken RH. Infectious diarrhea of infant rats produced by a rotavirus-like agent. J Virol. Oct; 52 (1)– [PMC free article].

Thus, rotavirus-induced diarrhea is a multistep and multifactorial event, in which fluid secretion and cell damage are observed in sequence, as shown in an intestinal cell line-based experimental model (Figure ).

A summary of the multiple mechanisms involved in the rotavirus-intestine interaction is given in Table Clinical signs and. HRV infection and RV enterotoxin treatment of HIEs caused physiological lumenal expansion detected by time-lapse microscopy, recapitulating one of the hallmarks of rotavirus-induced diarrhea.

These results demonstrate that HIEs are a novel pathophysiological model that will allow the study of HRV biology, including host restriction, cell type restriction, and virus-induced fluid secretion.